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Chronic Fatigue Syndrome Immediately following massage therapy, depressed mood, anxiety and stress hormone (cortisol) levels were reduced. Following 10 days of massage therapy, fatigue related symptoms, particularly anxiety and somatic symptoms, were reduced, as were depression, difficulty sleeping and pain. Stress hormone (cortisol) also decreased and dopamine increased. Field, T, Sunshine, W., Hernandez-Reif, M., Quintino, O., Schanberg, S., Kuhn, C., & Burman, I. (1997). Chronic fatigue syndrome: Massage therapy effects on depression and somatic symptoms in chronic fatigue syndrome. Journal of Chronic Fatigue Syndrome, 3, 43-51.